The 1940 United States Senate election in Maryland was held on November 5, 1940.
Incumbent Democratic Senator George L. P. Radcliffe was re-elected to a second term in office, fending off an intra-party challenge from businessman Howard Bruce and easily winning the general election over Republican ex-Governor Harry Nice. This was, since the start of direct popular election of senators, the first election for the Class 1 Senate seat in Maryland when an incumbent senator was re-elected.