The 1932 United States Senate election in Missouri took place on November 8, 1932, in Missouri. Incumbent Democratic Senator Harry B. Hawes did not seek re-election, and Democratic candidate Bennett Champ Clark was elected with 63.26% of the vote over former Mayor of St. Louis Henry Kiel. Clark slightly underperformed Franklin D. Roosevelt, who won 63.69% of the vote in the presidential election. He also notably carried the exact same counties Roosevelt carried in the Presidential Election
Hawes resigned his seat on February 3, 1933, and Clark was appointed to the vacancy before his full term began.
The Communist Party nominated Julius Pollack.