The 1928 United States Senate election in Maryland was held on November 5, 1928.
Incumbent Democratic Senator William Cabell Bruce ran for re-election to a second term in office, but was defeated by Republican former Governor Phillips Lee Goldsborough, who had been a failed candidate for Senate in 1916.
This is the last time a Republican not named Beall has won this seat, and the last time until 1952 that a Republican would be elected to the Class 1 Senate seat in Maryland.