The United States Senate election of 1926 in New York was held on November 2, 1926. Incumbent Republican Senator James Wolcott Wadsworth Jr. ran for re-election to a third term, but was defeated by Democrat Robert F. Wagner.
Incumbent Senator Wadsworth was opposed by hard-line prohibitionists, who instead supported Franklin W. Cristman at the Republican Convention.
After failing to qualify for a primary election against Senator Wadsworth, Cristman announced his campaign as an independent Republican. He supported Prohibition and was opposed to Wadsworth's position as a "wet" (or anti-Prohibition) Republican.