The 1922 United States Senate election in Nebraska took place on November 7, 1922. Incumbent Senator Gilbert M. Hitchcock ran for re-election to a third term. He was challenged in the general election by Republican Robert B. Howell, the Chairman of the Metropolitan Utilities District. Despite nationwide Democratic gains in the Senate, Hitchcock was defeated by Howell in a landslide.
After winning the primary, Wray withdrew from the race and endorsed Howell, declaring, "It would be morally wrong for me, or any other man, to divide the progressive vote and contribute in the least degree to the re-election of the reactionary, Hitchcock."