The 1922 United States Senate election in Michigan was held on November 7, 1922. Incumbent Republican Senator Charles E. Townsend ran for re-election to a third term in office, but was defeated by Democratic former Governor Woodbridge N. Ferris. Ferris was the first Democrat popularly elected to represent Michigan in the Senate, as Democrats last won a Senate seat in 1859, and last held this seat in 1857.