The 1921 Ohio State Buckeyes football team represented Ohio State University in the 1921 Big Ten Conference football season. The Buckeyes compiled a 5âÂÂ2 record while outscoring opponents 110âÂÂ14. The 14 points allowed came in Ohio State's only losses. The Buckeyes' 1921 loss to remains their last loss to a team from the state of Ohio.
Despite being in the Western Conference (Big Ten) together since 1913, this season had the first matchup between Ohio State and Minnesota.