The 1918 Case Scientists football team represented the Case School of Applied Science, now a part of Case Western Reserve University, during the 1918 college football season. The team's head coach was Pat Pasini.
Due to the Spanish flu pandemic, Case played the and games behind locked gates with no fans and cancelled their games with and . The game against was rescheduled from September 21 to midweek contest on November 6 and Hiram was added late in the year.