The 1916 United States Senate election in Washington was held on November 7, 1916. Incumbent Republican Miles Poindexter was running for a second term in office over Democratic former Senator George Turner and Socialist Bruce Rogers.
Primary elections were held on September 12. Poindexter overcame a strong primary challenge from U.S. Representative William E. Humphrey and college president Enoch Albert Bryan.
Thompson was unopposed for the Progressive nomination.