The 1916 United States Senate election in Nebraska took place on November 7, 1916. Incumbent Senator Gilbert Hitchcock, a Democrat, sought re-election in his first popular election. He won the Democratic primary and the cross-endorsement of the People's Independent party and faced former Congressman John L. Kennedy in the general election. Hitchcock won re-election as Democratic President Woodrow Wilson handily won the state in the presidential election.
On July 21, 1916, the Progressive Party withdrew its nominations and endorsed the slate of Republican candidates.