The 1916 United States Senate election in Maryland was held on November 7, 1916.
Incumbent Democratic Senator Blair Lee I ran for election to a full term in office, but was defeated in the Democratic primary by U.S. Representative David John Lewis. Lewis went on to lose the general election to Republican Joseph I. France, a professor of medicine and former state senator.
Lee received more raw votes than Lewis did, but Lewis received a higher share of the unit vote at the state convention.