There were four special elections to the United States House of Representatives in 1915:
|- ! | Joseph T. Johnson | | 1900 | | Incumbent resigned April 19, 1915 to become judge of the U.S. District Court for the Western District of South Carolina.<br>New member elected September 14, 1915.<br>Democratic hold. | nowrap |
|- ! | Joseph A. Goulden | | 1912 | | Incumbent died May 3, 1915.<br>New member elected November 2, 1915.<br>Republican gain. | nowrap |
|- ! | Edwin A. Merritt | | 1912 | | Incumbent died December 4, 1914.<br>New member elected November 2, 1915.<br>Republican hold. | nowrap |
|- ! | Sereno E. Payne | | 1889 | | Incumbent died December 10, 1914.<br>New member elected November 2, 1915.<br>Republican hold. | nowrap |
|- ! | colspan=3 | Vacant | | Rep.-elect William M. Brown (R) died January 31, 1915.<br>New member elected November 3, 1915.<br>Republican hold. | nowrap |