The 1915 Giro di Lombardia was the eleventh edition of the Giro di Lombardia cycle race and was held on 7 November 1915, over a course of . The race was won by Italian Gaetano Belloni, who reached the finish line at an average speed of , preceding his compatriots, and .
117 cyclists (of 164 signed up) departed from Milan and 55 completed the race.