The 1914 United States Senate election in Missouri took place on November 3, 1914, in Missouri. Incumbent Democratic Senator William J. Stone was re-elected to a third term in office. He defeated Thomas Akins of the Republican Party.
The Prohibition Party nominated Orange J. Hill, a member of the Drury College board of trustees and the Prohibition candidate in the 1904 gubernatorial election.
The Socialist Labor Party of America nominated J. W. Molineaux.