1910 in Argentine football saw Alumni regain the championship, winning its 9th title in 11 seasons.
The 1909 championship was reduced from 10 to 9 teams, with each team playing the other twice.
Gimnasia y Esgrima de Buenos Aires (promoted last year) made its debut at the top division while Argentino de Quilmes was relegated to Segunda División.
Argentina won the first tournament of the year, the South America Cup. The squad would then lose the Copa Lipton and Copa Premier Honor Argentino finals at the hands of Uruguay.