The 1910 United States House of Representatives elections in South Carolina were held on November 8, 1910, to select seven Representatives for two-year terms from the state of South Carolina. Six incumbents were re-elected and the open seat in the 2nd congressional district was retained by the Democrats. The composition of the state delegation thus remained solely Democratic.
Incumbent Democratic Congressman George Swinton Legaré of the 1st congressional district, in office since 1903, defeated James H. Lesesne in the Democratic primary and Republican Aaron P. Prioleau in the general election.
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Incumbent Democratic Congressman James O'H. Patterson of the 2nd congressional district, in office since 1905, was defeated in the Democratic primary by James F. Byrnes. He was unopposed in the general election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman Wyatt Aiken of the 3rd congressional district, in office since 1903, was unopposed in his bid for re-election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman Joseph T. Johnson of the 4th congressional district, in office since 1901, defeated Republican challenger Thomas Brier.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman David E. Finley of the 5th congressional district, in office since 1899, won the Democratic primary and was unopposed in the general election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman J. Edwin Ellerbe of the 6th congressional district, in office since 1901, won the Democratic primary and was unopposed in the general election.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman Asbury Francis Lever of the 7th congressional district, in office since 1901, defeated W.W. Roy in the Democratic primary and Republican R.H. Richardson in the general election.
|- | | colspan=5 |Democratic hold |-