The 1910 South Dakota gubernatorial election was held on November 8, 1910. Incumbent Republican Governor Robert S. Vessey ran for re-election to a second term. He faced two serious competitors in the Republican primary: colorful disbarred attorney George W. Egan and former Governor Samuel H. Elrod, and won the primary only with a narrow plurality. In the general election, he faced Democratic nominee Chauncey L. Wood, the Mayor of Rapid City. He improved on his margin from 1908, defeating Wood in a landslide.
Primary elections were held on June 7, 1910.