The 1910 Nebraska lieutenant gubernatorial election was held on November 8, 1910, and featured incumbent Nebraska Lieutenant Governor Melville R. Hopewell, a Republican, defeating Democratic nominee Ralph A. Clark as well as Socialist Party nominee George L. Slutter and Prohibition Party nominee Samuel Lichty.
The People's Independent Party, a remnant of the earlier populist movement, chose between the two democratic candidates for lieutenant governor. Although William H. Green edged out the victory in the primary, the People's Independent Party decided to endorse Ralph A. Clark instead, since he was the Democratic nominee and the party did not desire to split the vote with the Democrats in the general election.
Samuel Lichty ran unopposed for the Prohibition Party nomination. He was the secretary of the Richardson County Farm Mutual Insurance Company from Falls City, Nebraska.
George L. Slutter ran unopposed for the Socialist Party nomination. He was from Omaha, Nebraska.
On May 2, 1911, incumbent Nebraska Lieutenant Governor Melville R. Hopewell, who was reelected in this election, died while in office. After the death of Hopewell, John H. Morehead was considered to be the acting lieutenant governor due to his position as president pro tempore of the Nebraska Senate based on Article V, Section 18, of the Nebraska Constitution until another lieutenant governor was elected in the 1912 Nebraska lieutenant gubernatorial election.