The 1910 major league baseball season began on April 14, 1910. The regular season ended on October 15, with the Chicago Cubs and Philadelphia Athletics as the regular season champions of the National League and American League, respectively. The postseason began with Game 1 of the seventh modern World Series on October 17 and ended with Game 5 on October 23. The Athletics defeated the Cubs, four games to one, capturing their first championship in franchise history. Going into the season, the defending World Series champions were the Pittsburgh Pirates from the season.
The 1910 schedule consisted of 154 games for all teams in the American League and National League, each of which had eight teams. Each team was scheduled to play 22 games against the other seven teams of their respective league. This continued the format put in place for the season. This format would last until .
For the first time, Opening Day, which took place on April 14, featured all sixteen teams. The American League would see its final day of the regular season on October 9, while the National League would see its final day of the regular season was on October 15. The World Series took place between October 17 and October 23.
The 1910 season saw the following rule changes:
An asterisk (*) denotes the ballpark a team played the minority of their home games at
26 tie games (19 in AL, 7 in NL), which are not factored into winning percentage or games behind (and were often replayed again), occurred throughout the season.
The postseason began on October 17 and ended on October 23 with the Philadelphia Athletics defeating the Chicago Cubs in the 1910 World Series in five games.
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The Washington Senators would play their last games at the original National Park with a doubleheader on October 6 against the Boston Red Sox. The park burned down in March 1911 and the Senators moved into a new National Park for the start of the season.
The Chicago White Sox would play their last game at South Side Park on June 27, having played ten seasons there going back to their inaugural season, and opened White Sox Park on July 1, where they would go on to play for 81 seasons through .