The 1910 Campeonato Paulista, organized by the LPF (Liga Paulista de Football), was the 9th season of São Paulo's top association football league. AA das Palmeiras won the title for the 2nd time. No teams were relegated. AA das Palmeiras's Eurico, Paulistano's Rubens Salles and São Paulo Athletic's Herbert Boyes were the top scorers, each having scored 10 goals.
The championship was disputed in a double-round robin system, with the team with the most points winning the title.
After Internacional's expulsion from the league, three teams applied for membership in the league: Ypiranga and AA Vila Buarque, both from São Paulo, and , from Sorocaba. the three disputed a qualifying tournament, disputed in a single round-robin format, to define who would participate in the championship.