The 1900 United States presidential election in Mississippi took place on November 6, 1900. All contemporary 45 states were part of the 1900 United States presidential election. Voters chose nine electors to the Electoral College, which selected the president and vice president.
Mississippi was won by the Democratic nominees, former U.S. Representative William Jennings Bryan of Nebraska and his running mate Adlai Stevenson I of Illinois. They defeated the Republican nominees, incumbent President William McKinley of Ohio and his running mate Theodore Roosevelt of New York. Bryan won the state by a margin of 77.9%.
With 87.56% of the popular vote, Mississippi would prove to be Bryan's second strongest state in the 1900 presidential election only after South Carolina.
Bryan had previously won Mississippi against McKinley four years earlier and would later win the state again in 1908 against William Howard Taft.