There were six special elections to the United States House of Representatives in 1885 during the 48th and 49th Congresses.
|- ! | Alfred M. Scales | | Democratic | 1857<br/>1858 <br/>1874 | | Incumbent resigned December 30, 1884, when elected Governor of North Carolina.<br/>New member elected January 15, 1885 and seated January 28, 1885.<br/>Democratic hold.<br/>Winner had already been elected to the next term. | nowrap |
|- ! | Jonathan Chace | | Republican | 1880 | |Resigned January 26, 1885, when elected U.S. Senator.<br/>New member elected February 5, 1885 and seated February 12, 1885.<br/>Republican hold.<br/>Winner had already been elected to the next term. | nowrap |
|- ! | James K. Jones | | Democratic | 1880 | |Incumbent member-elect resigned during the previous Congress when elected U.S. senator.<br/>New member elected September 7, 1885 and seated December 7, 1885.<br/>Democratic hold. | nowrap |
|- ! | Reuben Ellwood | | Republican | 1882 | | Incumbent died July 1, 1885.<br/>New member elected November 3, 1885 and seated December 7, 1885.<br/>Republican hold. | nowrap |
|- ! | Samuel S. Cox | | Democratic | 1856<br/>1864 <br/>1868 | | Incumbent resigned to become U.S. Envoy Extraordinary and Minister Plenipotentiary to the Ottoman Empire.<br/>New member elected November 3, 1885.<br/>Democratic hold. | nowrap |
|- ! | William A. Duncan | | Democratic | 1882 | | Incumbent member-elect resigned during previous congress.<br/>New member elected November 3, 1885 and seated December 7, 1885.<br/>Democratic hold. | nowrap |