The 1878 United States House of Representatives election in Maine was held on September 9, 1878, to elect representatives from the state of Maine. Maine's five representatives in the House were apportioned according to the 1870 census. Representatives served in the 46th Congress from March 4, 1879, to March 4, 1881. Elections were held in midterms, coinciding with the state's gubernatorial elections.
The total results of each party in the 5 districts.
Incumbent Thomas B. Reed won re-election against all other candidates.
Incumbent William P. Frye won re-election against all other candidates.
Incumbent Stephen Lindsey won re-election against all other candidates.
Incumbent Llewellyn Powers of the Republican Party lost re-election to George W. Ladd of the Greenback Party.
Incumbent Eugene Hale of the Republican Party lost re-election to Thompson H. Murch of the Greenback Party.