Presidential elections were held in Argentina on 5, 6 and 7 September 1859 to choose the second president of the Argentine Confederation. Santiago Derqui was elected president.
The Buenos Aires Province seceded from the Confederation as the State of Buenos Aires on 11 September 1852 and did not participate in elections until 1862.
As none of the candidates obtained the majority of voters required by the constitution, Congress elected the vice president.