A special election to the United States House of Representatives for Florida's at-large congressional district was held October 6, 1845.
The winning candidate would serve a less-than-two-year term in the United States House of Representatives to represent Florida in the 29th Congress from October 6, 1845, to March 4, 1847.
The election was initially called for the Whig candidate, Edward Carrington Cabell, and Cabell was seated in the House of Representatives. However, a recount found the winner to actually be the Democratic candidate, William Henry Brockenbrough. Brockenbrough was seated immediately on January 24, 1846.
In the 1845 congressional election, David Levy Yulee, a Democrat, was elected to the United States House of Representatives. However, Yulee was jointly elected by the Florida Legislature to the United States Senate, and so resigned from the House of Representatives before taking his seat in order to take his seat in the Senate.