A special election was held in to fill two vacancies caused by the deaths of George Holcombe (J) on January 14, 1828, and Hedge Thompson (A) on July 23, 1828. The elections were held at the same time as the election for the 21st Congress.
Sinnickson and Randolph took their seats on December 1, 1828. Randolph was also elected to the 21st Congress.