Elections to the United States House of Representatives were held in Pennsylvania on October 14, 1806, for the 10th Congress.
In the previous elections, 17 Democratic-Republicans and 1 Federalist had been elected to represent Pennsylvania. There were two subsequent special elections which did not result in any seats changing parties. One seat held by a Democratic-Republican had become vacant and was not yet filled at the time of the election.
As in the previous election, there was a breakaway faction of the Democratic-Republican Party allied with the Federalists known as the tertium quids or Constitutional Republicans, which ran candidates in several districts. Several of the elected quids aligned with the Federalists on the federal level.
Pennsylvania was divided into 11 districts, of which four were plural districts with 11 Representatives between them, with the remaining 7 Representatives elected from single-member districts. The districts were:
Note: Many of these counties covered much larger areas than they do today, having since been divided into smaller counties
Fifteen incumbents (14 Democratic-Republicans and the sole Federalist) ran for re-election, of whom eleven won re-election. The incumbents Isaac Anderson (DR) and Christian Lower (DR), both of the did not run for re-election and one seat in the was vacant, the previous incumbent Michael Leib (DR) having resigned February 14, 1806. Two seats changed from Democratic-Republican to Federalist control.
Election results are unavailable for the .
Joseph Clay (DR) of the resigned March 18, 1808. A special election was held October 11, 1808, the same day as the 1808 general elections.