16S rRNA (guanine<sup>966</sup>-N<sup>2</sup>)-methyltransferase (, yhhF (gene), rsmD (gene), m2G966 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine<sup>966</sup>-N<sup>2</sup>)-methyltransferase. This enzyme catalyses the following chemical reaction
The enzyme efficiently methylates guanine<sup>966</sup> of the assembled 30S subunits in vitro.