16S rRNA (guanine<sup>527</sup>-N<sup>7</sup>)-methyltransferase (, ribosomal RNA small subunit methyltransferase G, 16S rRNA methyltransferase RsmG, GidB, rsmG (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine<sup>527</sup>-N<sup>7</sup>)-methyltransferase. This enzyme catalyses the following chemical reaction
The enzyme specifically methylates guanine<sup>527</sup> at N<sup>7</sup> in 16S rRNA.