16S rRNA (cytidine<sup>1409</sup>-2'-O)-methyltransferase (, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine<sup>1409</sup>-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction
The bifunctional enzyme from Mycobacterium tuberculosis.