16S rRNA (adenine<sup>1408</sup>-N<sup>1</sup>)-methyltransferase (, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine<sup>1408</sup>-N<sup>1</sup>)-methyltransferase. This enzyme catalyses the following chemical reaction
The enzyme provides a resistance through interference with the binding of aminoglycosides.