In enzymology, a 15-hydroxyprostaglandin-I dehydrogenase (NADP<sup>+</sup>) () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-, dienoate, and NADP<sup>+</sup>, whereas its 3 products are (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoa te:NADP<sup>+</sup> 15-oxidoreductase. Other names in common use include prostacyclin dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase, NADP<sup>+</sup>-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase, NADP<sup>+</sup>-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, and 15-hydroxyprostaglandin-I dehydrogenase (NADP<sup>+</sup>).