The 122nd Territorial Defense Brigade () is a military formation of the Territorial Defense Forces of Ukraine in Odesa Oblast. It is part of Operational Command South.
On 30 June 2018 the brigade was formed in Odesa Oblast. On 11 December 2018 300 to 500 reservist took part in a training exercise in Odesa. From 5 to 9 June 2019 a large scale exercise involving all battalions took place.
184th Battalion was formed in Artsyz and in early part of 2022 it moved to Bolhrad.
On 14 October, the brigade received its battle flag.
On 23 November soldiers from 185th Battalion shot down a S-300 missile using DShK heavy machine gun.
As of 2022 the brigade's structure is as follows: