11-Hydroxy-ÃÂ<sup>8</sup>-tetrahydrocannabinol (11-hydroxy-ÃÂ<sup>8</sup>-THC, alternatively numbered as 7-hydroxy-ÃÂ<sup>6</sup>-THC) is an active metabolite of ÃÂ<sup>8</sup>-THC, a psychoactive cannabinoid found in small amounts in Cannabis. It is an isomer of 11-OH-ÃÂ<sup>9</sup>-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970.
It retains psychoactive effects in animal studies with higher potency than ÃÂ<sup>8</sup>-THC but lower potency than 11-OH-ÃÂ<sup>9</sup>-THC. With widespread legal use of semi-synthetic ÃÂ<sup>8</sup>-THC in certain jurisdictions where ÃÂ<sup>9</sup>-THC remains illegal, 11-OH-ÃÂ<sup>8</sup>-THC is now an important metabolite for distinguishing between use of hemp-derived ÃÂ<sup>8</sup>-THC and natural ÃÂ<sup>9</sup>-THC.