The 101st Territorial Defense Brigade () is a military formation of the Territorial Defense Forces of Ukraine in Zakarpattia Oblast. It is part of Operational Command West.
In 2018, in Zakarpattia Oblast, the brigade was formed. From 19 to 28 September 2019, the brigade held large scale exercise for over 2,000 reservists.
Units of the brigade served in defence of Popasna in April, then defended Hirske, Serhiivka, Volodymyrivka and Spirne. Some troops from the brigade were serving in Sumy Oblast and Kharkiv Oblast in December 2022.
As of 2022 the brigade's structure is as follows: