101 North Main Street (formerly known as Bank of America Plaza or Bank of America Building) is a tall international style office building located on 101 North Main Street in downtown Greenville, South Carolina. The building has 16 floors and was built in 1974. At the time of its completion, it became the 2nd-tallest building in Greenville. As of February 2026, it is the 3rd-tallest building in Greenville.
In 2015, it was announced that the 3rd floor of the building would be transformed into a tech hub called "NEXT on Main".
In 2016, RealOp Investments bought the building from the Hughes Development Corporation for $22.5 million dollars. After the building's purchase, it would undergo a series of renovations. Renovations included modernizing the building's lobby, due to it being the first thing the public would see when they would walk into the building, the renovations also included renovating the bathrooms, and modernizing the building's facade.
In 2021, Canal Insurance announced that they will move their headquarters from 400 East Stone Avenue to 101 North Main Street. Canal Insurance also gained the signage rights for the building.
The building is a part of One City Plaza. Amenities include a cafe, a fitness center, and a courtyard.