1-Naphthoic acid

1-Naphthoic acid is an organic compound with the formula C₁₀H₇CO₂H. It is one of two isomeric monocarboxylic acids of naphthalene, the other one being 2-naphthoic acid. In general the hydroxynaphthoic acids are more widely used than the parent naphthoic acids.

Synthesis and reactions

1-Naphthoic acid can be prepared by carboxylation of the Grignard reagent generated from 1-bromonaphthalene.

1-Naphthoic acid is a substrate for C-H activation reactions.

Catalytic hydrogenation of 1-Naphthoic acid gives 1,2,3,4-Tetrahydro-1-naphthoic acid [1914-65-4]. This is used in the synthesis of Tetryzoline.

See also

• Hydroxynaphthoic acids
• Classes of synthetic cannabinoids
• Naphthoylindoles, or 3-(1-naphthoyl)indoles
• Naphthoylpyrroles, or 3-(1-naphthoyl)pyrroles
• Natural products containing 1-naphthoic acid moiety
• Neocarzinostatin (as 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)
• Azinomycin B (as 3-methoxy-5-methyl-1-naphthoate)

References