1,8-Naphthyridine is an organic compound with the formula C<sub>8</sub>H<sub>6</sub>N<sub>2</sub>. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.
With flanking nitrogen centers, 1,8-naphthyridine serves as a binucleating ligand in coordination chemistry.