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1,2,4-Dithiazolidine-3,5-dione

1,2,4-Dithiazolidine-3,5-dione (DTS) is the heterocyclic compound with the formula . In terms of functional groups, the molecule contains a disulfide (-S-S-) and an imido group ((RC(O)]2NH).

The title compound is prepared by the reaction of ethyl thiocarbonate and chlorocarbonylsulfenyl chloride followed by treatment of the intermediate with hot hydrochloric acid:

N-substituted derivatives can be prepared by N-alkylation:

The compound has been evaluated in several biochemical contexts including controlled release of hydrogen sulfide.

References