(âÂÂ)-ô-Cadinene synthase (EC 4.2.3.97) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (âÂÂ)-ô-cadinene-forming). This enzyme catalyses the following chemical reaction
The cyclization mechanism involves an intermediate nerolidyl diphosphate.