(âÂÂ)-ò-Caryophyllene synthase (EC 4.2.3.57, ò-caryophyllene synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((âÂÂ)-ò-caryophyllene-forming). This enzyme catalyses the following chemical reaction
This enzyme is widely distributed in higher plants.