(+)-Germacrene D synthase (EC 4.2.3.77) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-germacrene-D-forming). This enzyme catalyses the following chemical reaction
This enzyme requires Mg<sup>2+</sup>, Mn<sup>2+</sup>, Ni<sup>2+</sup> or Co<sup>2+</sup>.