(+)-ó-Cadinene synthase (EC 4.2.3.92) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-ó-cadinene-forming). This enzyme catalyses the following chemical reaction
The enzyme from the melon, Cucumis melo, forms mainly ô- and ó-cadinene.