(+)-ñ-Santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) (EC 4.2.3.50, SBS) is an enzyme with systematic name (2Z,6Z)-farnesyl diphosphate lyase (cyclizing; (+)-ñ-santalene-forming). This enzyme catalyses the following chemical reaction
The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate.